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How to interpret IGF-1 and growth hormone stimulation tests
  1. Xanthippi Tseretopoulou1,
  2. Talat Mushtaq2
  1. 1 Paediatric Endocrinology, Addenbrooke's Hospital, Cambridge, UK
  2. 2 Paediatric Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Talat Mushtaq; talat.mushtaq{at}


You are seeing an 11-year-old boy in a general paediatric clinic referred with short stature. His height is below the 0.4th centile. The mid-parental height is on 50th centile. Baseline investigations, including renal and liver function, coeliac screen and thyroid function tests are normal. You have a suspicion of growth hormone deficiency. Should you check an insulin-like growth factor-1 level or proceed with a growth hormone provocation test? The current paper will aim to give an overview of these tests and factors to consider when interpreting the results.

  • endocrinology
  • general paediatrics
  • growth

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; externally peer reviewed.