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Medicines Update
Fifteen-minute consultation: Pharmacogenomics: a guide for busy clinicians
  1. Christopher Mark Parry1,2,
  2. Daniel Hawcutt1,2
  1. 1 Members of Liverpool Health Partners, University of Liverpool, Liverpool, Merseyside, UK
  2. 2 Alder Hey Clinical Research Facility, NIHR, Liverpool, UK
  1. Correspondence to Dr Christopher Mark Parry, Gastroenterology, Alder Hey Children’s NHS Foundation Trust, Liverpool L12 2AP, UK; christopher.parry1{at}nhs.net

Abstract

The ultimate goal of pharmacogenomics is to understand how the effects of interindividual genetic variation impact on the response of patients to treatments and in turn optimise those treatments while minimising potential side effects. This review article provides a brief overview of pharmacogenomics, focusing on the methods used to understand how genes of interest are identified, how pharmacogenomics is currently used within paediatric clinical practice within the UK, potential areas for future use and some of the caveats specific to paediatric medicine.

  • pharmacology
  • paediatric practice
  • genetics

https://doi.org/10.1136/archdischild-2019-316971

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    Footnotes

    • Funding This is a summary of independent research funded by the University of Liverpool and carried out at the National Institute for Health Research (NIHR), Alder Hey Clinical Research Facility.

    • Disclaimer The views expressed are those of the author(s) and not necessarily those of the University of Liverpool, NHS, the NIHR or the Department of Health.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.

    • Patient consent for publication Not required.