Some 95–98% of men with cystic fibrosis (CF) have azoospermia because of aplasia of the vasa deferentia. Pregnancy may be achieved, however, in nearly two-thirds of couples in which the man has CF by use of microsurgical epididymal sperm aspiration and intracytoplasmic sperm injection. Several studies have suggested that adolescents and young men with CF need, and want, more information about their sexual and reproductive …