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Study design: Randomised, double-blinded, triple-arm, placebo controlled trial in a tertiary care emergency department (ED) in the USA.1
Patients: 122 adults aged ≥18 years, presenting to the ED with nausea or vomiting (eg, abdominal pain and vomiting) with a self reported nausea score of ≥3/10.
Intervention: Inhaled isopropyl alcohol and oral placebo.
Comparison: Inhaled saline solution and 4 mg oral ondansetron.
Non-placebo arm: Inhaled isopropyl alcohol and 4 mg oral ondansetron, included to counteract subjects guessing that the inhaled saline was the placebo. Patients were advised to take the oral solution then take deep inhalations of the medical pad 1–2 cm away from the nose, as frequently as required to achieve nausea relief. Exclusion factors included recent intake of medications contraindicating alcohol, blocked nares (eg, rhinitis), known prolonged QT interval, suspected or known pregnancy …
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