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Mometasone furoate nasal spray was more effective for symptom relief of acute rhinosinusitis than amoxicillin or placebo

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In patients with acute, uncomplicated rhinosinusitis lasting ⩾7 days, what is the relative effectiveness of mometasone furoate nasal spray, amoxicillin, and placebo?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Allergy & immunology ★★★★★☆☆ Respirology ★★★★★☆☆

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

unclear allocation concealment.*

Embedded ImageBlinding:

blinded (patients and healthcare providers).*

Embedded ImageFollow up period:

up to 29 days.

Embedded ImageSetting:

71 medical centres in 14 countries.

Embedded ImagePatients:

981 patients ⩾12 years of age (mean age 35 y, 66% women) with signs and symptoms of acute rhinosinusitis for ⩾7 days but ⩽28 days and major symptom score (MSS) ⩾5 but ⩽12, with ⩽3 of 5 symptoms rated as severe (based on the sum of scores for rhinorrhoea, postnasal drip, nasal congestion/stuffiness, sinus headache, and facial pain/pressure/tenderness).

Embedded ImageIntervention:

mometasone furoate nasal spray, 200 μg, once daily for 15 days (n  =  243); mometasone spray, 200 μg, twice daily for 15 days (n  =  235); amoxicillin, 500 mg, …

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