Patients with β-thalassemia major (BTM) require regular blood transfusions, supported by
appropriate iron chelation therapy (ICT), throughout their life. β-thalassemia is a global …

Purpose To explore the use and reproducibility of magnetic resonance‐derived myocardial
T1 mapping in patients with iron overload. Materials and Methods The research received …

With the developing COVID‐19 pandemic, patients with inherited anaemias require specific
advice regarding isolation and changes to usual treatment schedules. The National …

Background Sickle cell disease (SCD) is a devastating, multisystemic disorder that affects
millions of people worldwide. The earliest clinical manifestations of SCD can affect infants as …

While supportive care remains the best option for most well children with sickle cell disease
(SCD), increasing awareness of early signs of chronic organ damage in childhood has …

Faced with the rapidly evolving COVID-19 pandemic, in March 2020 the UK Government
advocated strict self-isolation ('shielding') to protect extremely vulnerable patient groups …

Each year, blood transfusions save millions of lives. However, under current blood-matching
practices, sensitization to non–self-antigens is an unavoidable adverse side effect of …

Excessive intravascular release of lysed cellular contents from damaged red blood cells
(RBCs) in patients with sickle cell anemia (SCA) can activate the inflammasome, a …

During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles
and reduce its surface area and volume. Here we show this involves a novel process …

Summary The International Collaboration for Transfusion Medicine Guidelines (ICTMG) has
published guidance on transfusion for haemoglobinopathies. To give a UK perspective on …