Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic
regulators invariably accompany tumorigenesis. Many chemotherapeutic agents induce …

Targeted cancer therapies exploit the continued dependence of cancer cells on oncogenic
mutations. Such agents can have remarkable activity against some cancers, although …

The use of parenteral nutrition (PN) is well established within neonatal units in the UK.
Although preterm infants are among the highest users of PN within any patient group …

Freud's developmental theory on psychosexual development was among the first attempts to
bring psychology under the same scientific structure and methodology of medicine. This …

Objectives: Describe conduct disorder. Summarize the history and exam of a patient with
conduct disorder. Review strategies for managing conduct disorder. Outline the clinical …

The major component of the epidermis, keratinocytes, must continuously proliferate and
differentiate to form the mechanical and water permeability barrier of the skin. Our previous …

Diseased skin often exhibits a deregulated program of the keratinocyte maturation
necessary for epidermal stratification and function. Protein kinase D (PKD), a …

A term baby girl is admitted to the neonatal unit following concerns regarding abnormal
movements noted on the postnatal ward. She is reported to have had tonic posturing of the …

Elevated extracellular potassium concentrations ([K+] e) are known to stimulate aldosterone
secretion from adrenal glomerulosa cells in vivo and in vitro. The mechanism is thought to …

Much data in the literature suggest a role for protein kinase C (PKC) in regulating
keratinocyte proliferation and differentiation. Nevertheless, the exact role of this family of …