Abstract Until recently, thrombocytopenia 2 (THC2) was considered an exceedingly rare
form of autosomal dominant thrombocytopenia and only 2 families were known. However …

Sickle cell disease (SCD) is an inherited red blood cell disorder caused by a structural
abnormality of hemoglobin called sickle hemoglobin (HbS). Clinical manifestations of SCD …

Background Chronic red blood cell transfusion is the first-line treatment for severe forms of
thalassaemia. This therapy is, however, hampered by a number of adverse effects, including …

The objective of the present article is to highlight the need for attention to Quality of Life of
patients with Sickle Cell Disease living in Italy. The transformation of sickle cell disease from …

Background Bernard-Soulier syndrome is a very rare form of inherited thrombocytopenia
that derives from mutations in GPIbα, GPIbβ, or GPIX and is typically inherited as a recessive …

Iron overload in β‐thalassemia major (TM) typically results in iron‐induced cardiomyopathy,
liver disease, and endocrine complications. We examined the incidence and progression of …

Background—Cardiovascular magnetic resonance (CMR) plays a key role in the
management of thalassemia major patients, but few data are available in pediatric …

Chronic blood transfusions are responsible to cause iron overload, which leads to several
complications to end organs and osteoporosis. Iron chelation is needed to remove iron …

Pulmonary arterial hypertension (PAH) is a life-threatening complication of β-thalassemia,
especially in untransfused patients with thalassemia intermedia. Pinto and colleagues …

Patients with β-thalassemia show 5-fold increase in agestandardized lethality due to SARS-
CoV-2 infection, representing a high-risk population compared with age-and sex-matched …