Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder
and is classified by subtype according to International League of Associations for …

Abstract Objectives The European Single Hub and Access point for paediatric
Rheumatology in Europe initiative aimed to optimize care for children with rheumatic …

Juvenile-onset systemic lupus erythematosus (jSLE) accounts for up to 20% of all SLE
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …

Aicardi–Goutières syndrome is an inflammatory disease occurring due to mutations in any of
TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR or IFIH1. We report on 374 …

The type I interferon system is integral to human antiviral immunity. However, inappropriate
stimulation or defective negative regulation of this system can lead to inflammatory disease …

Objective. To revise the current juvenile idiopathic arthritis (JIA) International League of
Associations for Rheumatology (ILAR) classification criteria with an evidence-based …

Background Adalimumab, a fully human anti–tumor necrosis factor α monoclonal antibody,
is effective in the treatment of juvenile idiopathic arthritis (JIA). We tested the efficacy of …

Multiple acyl-CoA dehydrogenation deficiency (MADD) is a disorder of fatty acid, amino acid
and choline metabolism that can result from defects in two flavoproteins, electron transfer …

Recent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an
achievable goal for most patients. Reaching this target leads to improved outcomes. The …

We studied ten individuals from eight families showing features consistent with the immuno-
osseous dysplasia spondyloenchondrodysplasia. Of particular note was the diverse …