[HTML][HTML] From theory to practice: translating whole-genome sequencing (WGS) into the clinic

F Balloux, OB Brynildsrud, L Van Dorp, LP Shaw… - Trends in …, 2018 - cell.com
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting
infections and providing patients with optimal drug regimens require timely strain …

Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

EC Rosser, K Oleinika, S Tonon, R Doyle, A Bosma… - Nature medicine, 2014 - nature.com
Regulatory B cells (Breg cells) differentiate in response to inflammation and subsequently
restrain excessive immune responses via the release of interleukin-10 (IL-10). However, the …

Molecular techniques for diagnosing prosthetic joint infections

JC Hartley, KA Harris - Journal of Antimicrobial Chemotherapy, 2014 - academic.oup.com
Prosthetic joint infections (PJI) can be broadly classed into two groups: those where there is
a strong clinical suspicion of infection and those with clinical uncertainty, including 'aseptic …

Development of broad-range 16S rDNA PCR for use in the routine diagnostic clinical microbiology service

KA Harris, JC Hartley - Journal of medical microbiology, 2003 - microbiologyresearch.org
The aim of the present study was to develop a broad-range PCR based on bacterial 16S
rDNA for use in the routine diagnostic clinical microbiology service. The optimization and …

A structure in the early Universe at z ∼ 1.3 that exceeds the homogeneity scale of the RW concordance cosmology

RG Clowes, KA Harris, S Raghunathan… - Monthly Notices of …, 2013 - academic.oup.com
A large quasar group (LQG) of particularly large size and high membership has been
identified in the DR7QSO catalogue of the Sloan Digital Sky Survey. It has characteristic size …

[HTML][HTML] Differing prevalence and diversity of bacterial species in fetal membranes from very preterm and term labor

HE Jones, KA Harris, M Azizia, L Bank, B Carpenter… - PloS one, 2009 - journals.plos.org
Background Intrauterine infection may play a role in preterm delivery due to spontaneous
preterm labor (PTL) and preterm prolonged rupture of membranes (PPROM). Because …

Whole-Genome Sequencing and Epidemiological Analysis Do Not Provide Evidence for Cross-transmission of Mycobacterium abscessus in a Cohort of Pediatric …

KA Harris, A Underwood, DTD Kenna… - Clinical infectious …, 2015 - academic.oup.com
Background. Mycobacterium abscessus has emerged as a major pathogen in cystic fibrosis
(CF) patients and has been associated with poor clinical outcomes, particularly following …

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study

RM Doyle, DM O'sullivan, SD Aller… - Microbial …, 2020 - microbiologyresearch.org
Antimicrobial resistance (AMR) poses a threat to public health. Clinical microbiology
laboratories typically rely on culturing bacteria for antimicrobial-susceptibility testing (AST) …

[HTML][HTML] Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an …

M Belay, B Tulu, S Younis, DA Jolliffe… - The Lancet …, 2021 - thelancet.com
Background Haematopoietic stem cells expressing the CD34 surface marker have been
posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis …

Mycobacterium abscessus infection in cystic fibrosis: molecular typing and clinical outcomes

KA Harris, DTD Kenna - Journal of medical microbiology, 2014 - microbiologyresearch.org
Mycobacterium abscessus is a significant pathogen in the cystic fibrosis patient population.
PCR amplification and sequencing can provide accurate subspecies identification, and can …