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Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing

International Journal of Obesity volume 25, pages 354–358 (2001)Cite this article

Abstract

OBJECTIVE: To investigate whether weight adjusted ciprofloxacin dosing results in comparable target site concentrations in obese and lean subjects.

DESIGN: Comparative study in two populations.

SUBJECTS: Twelve obese subjects (mean weight 122±22.6 kg, 28–52 y, male : female ratio 4 : 8) and 12 age- and sex-matched lean controls (mean weight 59±8.6 kg).

METHODS: Sampling of interstitial space fluid by means of calibrated in vivo microdialysis after a weight-adjusted intravenous bolus dose of 2.85 mg/kg ciprofloxacin. Analysis of drug concentration by high pressure liquid chromatography.

RESULTS: We found significantly higher peak and trough levels of ciprofloxacin in plasma for obese subjects (9.97±5.64 and 0.44±0.10 µg/ml vs 2.59±1.06 and 0.19±0.09 µg/ml in lean subjects, P<0.05), while concentration–time curves of interstitial fluid of muscle and subcutaneous fat did not differ between the groups. Tissue penetration, expressed as AUCtissue/AUCplasma ratio was significantly lower in obese subjects (0.45±0.27 vs 0.82±0.36, P<0.01).

CONCLUSION: We conclude that the penetration process into the interstitial space fluid is impaired in obese subjects. Therefore antibiotic doses need not be adjusted for an increase in fat/water ratio. Weight-adjusted dosing based on actual body weight will yield adequate tissue levels for ciprofloxacin.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria

    UM Hollenstein, M Brunner & M Müller

  2. Division of Infectious Diseases, Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria

    UM Hollenstein

  3. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Vienna University Hospital, Vienna, Austria

    R Schmid

Authors
  1. UM Hollenstein
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  2. M Brunner
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  3. R Schmid
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  4. M Müller
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Correspondence to M Müller.

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Hollenstein, U., Brunner, M., Schmid, R. et al. Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing. Int J Obes 25, 354–358 (2001). https://doi.org/10.1038/sj.ijo.0801555

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