Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral medicinePilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy
Section snippets
Subjects and Methods
For this trial, one group of physicians served for recruitment of patients (X), and a different group of physicians were involved in evaluation of therapy and outcomes (Y). The diagnosis of RAS was made by evaluating clinical aspects of the oral ulcers19 as well as a detailed history of the periodic recurrence of lesions. A total of 98 patients affected by aphthous lesions were enrolled and met the inclusion and exclusion criteria listed.
Results
During the month preceding the trial, 102 lesions in patients of group A, 98 lesions in group B, and 94 lesions in group C were recorded.
Discussion
In this study, we evaluated the efficacy of systemic montelukast in comparison with systemic prednisone in the control of RAS. Montelukast is an oral leukotriene (LT) receptor antagonist. Leukotrienes (LTs) are a family of paracrine hormones derived from the oxidative methabolism of polyunsaturated fatty acids, particularly arachidonic acid. It is known that these drugs prevent LT binding and the subsequent activation of LT receptors.18 Phospholipid undergoes metabolic degradation to form
References (34)
- et al.
Oral ulcers
Med Clin
(2005) - et al.
Recurrent aphthous stomatitis
Dent Clin North Am
(2005) - et al.
Triamcinolone acetonide versus chlorhexidine for treatment of recurrent stomatitis
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1993) - et al.
Pentoxifylline in the treatment of orogenital aphthosis and Behçet's syndrome
Med Clin
(2000) - et al.
Recurrent aphthous ulcers today: a review of the growing knowledge
Int J Oral Maxillofac Surg
(2004) - et al.
Randomized, double-blind, placebo-controlled study of montelukast for treating perennial allergic rhinitis
Ann Allergy Asthma Immunol
(2005) - et al.
The role of leukotrienes in allergic rhinitis
Ann Allergy Asthma Immunol
(2005) - et al.
Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs
Burns
(2005) - et al.
Effect of montelukast on polymorphonuclear leukocyte functions in asthmatic patients
Int Immunopharmacol
(2003) - et al.
Norwegian LongoVital and recurrent aphthous ulceration: a randomized, double-blind, placebo-controlled study
Oral Dis
(2005)