Original articleMyopia as a Risk Factor for Open-Angle Glaucoma: A Systematic Review and Meta-Analysis
Section snippets
Search Strategy
Two of the authors (MMV and FGJM) independently conducted a systematic search of PubMed and Embase up to October 27, 2010, in accordance with the MOOSE consensus statement.19 The search terms used in PubMed included (“myopia”[MeSH Terms] OR “myopia”[All Fields]) OR myopic[All Fields] OR (“refractive errors”[MeSH Terms] OR (“refractive”[All Fields] AND “errors”[All Fields]) OR “refractive errors”[All Fields] OR (“refractive”[All Fields] AND “error”[All Fields]) OR “refractive error”[All
Results
Figure 1 shows the selection process. The literature search yielded 1176 articles, 527 from PubMed and 649 from Embase, of which 70 were reviewed in full text. After a thorough review, 13 studies met the inclusion criteria for this meta-analysis.21, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38 All studies were population based: 11 cross-sectional,28, 29, 30, 31, 32, 33, 34, 35, 36, 37 1 case-control,27 and 1 longitudinal cohort study.38 Six studies were conducted in Asia,21, 32, 33, 34, 35, 36
Discussion
The findings from this meta-analysis indicate that individuals with myopia have an approximately doubled risk of developing OAG in comparison with individuals without myopia. The pooled ORs were 2.46 (95% CI, 1.93–3.15) for high myopia and 1.77 (95% CI, 1.41–2.23) for low myopia, with a cutoff value of −3 D.
Although the point estimate of the pooled OR of high myopia was larger than that of low myopia, the difference was small. A more pronounced dose-response relationship would have reinforced
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Manuscript no. 2010-1656.
Funding: This research was supported by the University Medical Center Groningen, stichting Nederlands oogheelkundig onderzoek, algemene Nederlandse vereniging ter voorkoming van blindheid, oogfonds, glaucoomfonds, and stichting blindenhulp, all in The Netherlands. The funding organizations had no role in the design, conduct, analysis or publication of this research.
Financial Disclosure(s): The author (s) have no proprietary or commercial interest in any materials discussed in this article.