Elastase 1 and chymotrypsin B in pancreatic juice and feces
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The prevalence and impact of low faecal elastase-1 in community-based patients with type 2 diabetes
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2017, Advances in Clinical ChemistryCitation Excerpt :An algorithm to assist with diagnosing pancreatic insufficiency is shown (Fig. 1). Pancreatic elastase 1 is an enzyme of the pancreatic juice that is highly stable during passage in the gastrointestinal tract [57]. The concentration of elastase 1 can be measured in the feces using an enzyme-linked immunosorbent assay on a spot fecal sample [58,59].
Preoperative fecal elastase-1 is a useful prognostic marker following curative resection of pancreatic cancer
2017, HPBCitation Excerpt :In this retrospective study of patients undergoing pancreatic resection for cancer, we demonstrated that FE-1 ≥200 μg/g, no lymph node metastasis and completion of adjuvant chemotherapy were independent prognostic factors for disease-free survival. To assess exocrine dysfunction of the pancreas, we used FE-1, a pancreatic enzyme that is highly stable during gastrointestinal passage and is enriched six-fold in feces.22 The FE-1 test requires only a single random stool sample and early studies of FE-1 showed good correlation with the results of direct exocrine functional tests.23,24
Discoveries and techniques that have contributed to improving the treatment of pancreatic diseases
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