Original articlePharmacokinetics and efficacy of chlorpheniramine in children☆,☆☆
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Cited by (51)
Pharmacokinetics and pharmacodynamics of d-chlorpheniramine following intravenous and oral administration in healthy Thoroughbred horses
2013, Veterinary JournalCitation Excerpt :Intracutaneous injection of histamine (histamine intradermal test) is one of the most popular tests used to evaluate the pharmacodynamics of antihistamines in the skin (Juhlin, 1995; Russell et al., 1998; Grant et al., 1999; Simons et al., 2002; Cook et al., 2004). Furthermore, the efficacy of CPM in different age groups has also been investigated using a histamine intradermal test and pharmacokinetic studies (Simons et al., 1982, 1990). However, despite studies of other antihistamines (clemastine, fexofenadine and cetirizine) in horses (Törneke et al., 2003; Olsén et al., 2006, 2008), the pharmacodynamics and pharmacokinetics of CPM have not been reported.
Levocetirizine: Pharmacokinetics and pharmacodynamics in children age 6 to 11 years
2005, Journal of Allergy and Clinical ImmunologyCitation Excerpt :In pharmacokinetic and pharmacodynamic studies of H1-antihistamines, although outcome measures such as blood tests and skin tests are highly objective, they are inherently invasive, and the studies therefore present unique challenges in children.2,4 Study designs do not usually involve a placebo control,7-20 not only because of ethical constraints and parental concerns about the use of placebo, but also because a potent H1-antihistamine suppresses wheals and flares by up to 100%,5,6,12,13 thus making it difficult to maintain double-masked observations and measurements. The objective, standardized, histamine-induced wheal-and-flare bioassay is useful for studying the onset, amount, and duration of activity of H1-antihistamines.
The clinical pharmacology of brompheniramine in children
1999, Journal of Allergy and Clinical ImmunologyEffect of chlorpheniramine on the pharmacokinetics of and response to chloroquine of Nigerian children with falciparum malaria
1999, Transactions of the Royal Society of Tropical Medicine and HygieneComparative efficacy of chloroquine/chlorpheniramine combination and mefloquine for the treatment of chloroquine-resistant Plasmodium falciparum malaria in Nigerian children
1997, Transactions of the Royal Society of Tropical Medicine and HygieneEnhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children
1997, Transactions of the Royal Society of Tropical Medicine and Hygiene
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This project was supported by the Children's Hospital of Winnipeg Research Foundation, Inc., and by the Medical Research Council of Canada.
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Presented at the 37th Annual Meeting of the American Academy of Allergy, San Francisco, 1981.
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Dr. F. E. R. Simons is a Queen Elizabeth II Scientist.