Possible participation of insulin in the control of vascular permeability

doi:10.1016/0014-2999(74)90030-2

European Journal of Pharmacology

Volume 29, Issue 2, December 1974, Pages 298-306

https://doi.org/10.1016/0014-2999(74)90030-2 Get rights and content

Abstract

Swelling induced in the rat's paw by chemical irritants has previously been shown to be markedly reduced in diabetic rats. Since diabetic animals rendered normoglycemic still presented inhibited responses whereas insulin administration reversed the inhibition, insulin might be expected to influence the development of the oedema. This might be done either directly or through an exacerbated action of adrenal corticosteroids secondary to insulin deficiency. Swelling reactions (dextran, carrageenin), as well as vascular permeability evoked by electrical stimulation of sensory nerves are now shown to be reduced in diabetic-adrenalectomized animals, as much as in diabetic rats, thus suggesting that the inhibition is not likely to depend on an anti-inflammatory action of corticosteroids. Electron microscopic investigation revealed that subdermal vessels of normal rats following i.d. injections of histamine were congested and endothelial openings easily found. In contrast, the endothelial junctions were usually closed in diabetic rats. These functional alterations might be related to insulin deficiency. It is concluded that the integrity of microcirculatory responses to noxious stimuli might, at least partially, depend on the availability of insulin.

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^☆: Partly supported by grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).

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Possible participation of insulin in the control of vascular permeability☆

Abstract

Biochem. Pharmacol.

Specificité humorale du glucose

L'Union Méd. Can.

Sensitization by insuline to the dextran anaphylactoid reaction

Can. J. Biochem. Physiol.

The passage of colloidal particles across the dermal capillary under the influence of histamine

Quart. J. Exptl. Physiol.

Inhibitory effects of carbohydrates on histamine release and mast cells disruption by dextran

Brit. J. Pharmacol.

Pituitary ACTH and plasma free corticosteroids following bilateral adrenalectomy in the rat