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MPGN type I induced by granulocyte colony stimulating factor

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Abstract 

We report a girl with severe congenital neutropenia who has received long-term granulocyte-colony stimulating factor (G-CSF) therapy and has developed macroscopic hematuria, proteinuria, and decreased renal function associated with biopsy-proven membranoproliferative glomerulonephritis (MPGN) type I. Temporary discontinuation of G-CSF therapy as well as the use of glycosylated G-CSF has resulted in improvement in renal manifestations. We postulate that the MPGN was G-CSF- induced. Long-term G-CSF therapy should be used with great caution and close surveillance of kidney function.

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Authors and Affiliations

  1. Pediatric Nephrology Unit, Rambam Medical Center, P.O. Box 9602, Haifa 31096, Israel e-mail: d_magen@rambam.health.gov.il Tel.: +972-4-8543237, Fax: +972-4-8543473, , , , , , IL

    D. Magen & Israel Zelikovic

  2. Department of Pediatrics, Rambam Medical Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel, , , , , , IL

    Hana Mandel & Moshe Berant

  3. Department of Pathology, Rambam Medical Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel, , , , , , IL

    Ofer Ben-Izhak

Authors
  1. D. Magen
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  2. Hana Mandel
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  3. Moshe Berant
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  4. Ofer Ben-Izhak
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  5. Israel Zelikovic
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Additional information

Received: 7 August 2001 / Revised: 2 January 2002 / Accepted: 4 January 2002

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Magen, D., Mandel, H., Berant, M. et al. MPGN type I induced by granulocyte colony stimulating factor. Pediatr Nephrol 17, 370–372 (2002). https://doi.org/10.1007/s00467-002-0847-9

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  • DOI: https://doi.org/10.1007/s00467-002-0847-9

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