Central nervous system disease | Microcephaly Hearing impairment Seizures Hydrocephalus Motor deficits Intracranial calcifications |
Ophthalmological disease with subsequent visual impairment | Microphthalmia Chorioretinitis (usually bilateral) Retinal scarring Strabismus Nystagmus Cataract |
Hepatic disease | Hepatosplenomegaly Jaundice |
Cardiorespiratory disease | Pneumonitis Myocarditis |
Systemic features | Rash (may be ‘blueberry-muffin’) Fever Bone marrow suppression (thrombocytopenia, anaemia) |