Table 1

A recommendation for tumour surveillance in patients with hemihypertrophy: 

InvestigationFrequency
Genetics opinion: refer all patientsOnce following initial paediatric consult
Abdominal ultrasound scan: initially for all patients and post-genetic testing for those at >5% risk of tumours3 monthly, no less frequently than three times a year, until age 5–7 years
Serum alpha fetoprotein: consider for those with methylation of IC2 defects or paternal uniparental disomy3 monthly until age 4 years
If serum alpha fetoprotein rises:
Repeat in 1 month and discuss with paediatric oncologist
Clinician examination of the abdomen for massesAt clinic review, at least yearly, until discharge