Recommended doses for vitamin-responsive epilepsy in neonates
| Drug/condition | Dose |
|---|---|
| Biotin | 5 mg orally/NGT twice a day, can increase up to 10 mg twice a day |
| Follinic acid | 5 mg orally/NGT twice a day |
| Pyridoxine | 100 mg intravenous trial dose (if positive, can be given orally 15 mg/kg/day in divided doses to a maximum of 500 mg) |
| Pyridoxal phosphate | Surtees: 10 mg/kg/dose 2 h apart orally as trial Baxter: 50 mg/kg/day in divided doses for 2 weeks* |
Adapted from references 5 and 6. *Authors’ current practice.
NGT, nasogastric tube.