Table 3

Recommended doses for vitamin-responsive epilepsy in neonates

Biotin5 mg orally/NGT twice a day, can increase up to 10 mg twice a day
Follinic acid5 mg orally/NGT twice a day
Pyridoxine100 mg intravenous trial dose (if positive, can be given orally 15 mg/kg/day in divided doses to a maximum of 500 mg)
Pyridoxal phosphateSurtees: 10 mg/kg/dose 2 h apart orally as trial
Baxter: 50 mg/kg/day in divided doses for 2 weeks*
  • Adapted from references 5 and 6. *Authors’ current practice.

  • NGT, nasogastric tube.