Table 3

Quadruple therapy5

DrugDosingDurationSide effects
Rifampacin10 mg/kg (maximum 450 mg if <50 kg or 600 mg if >50 kg)6 monthsLiver toxicity
Isoniazid5–10 mg/kg (maximum 300 mg)6 monthsLiver toxicity and peripheral neuropathy (common)
Pyrazinamide35 mg/kg (maximum 1.5 g if <50 kg or 2 g if >50 kg)First 2 monthsLiver toxicity
Ethambutol15 mg/kg once a dayFirst 2 monthsVisual disturbance (colour blindness, loss of acuity and visual field loss)