Differences between IgE- and non–IgE-mediated food allery7 13
| IgE mediated | Non–IgE mediated | |
|---|---|---|
| History | ||
| Onset of symptoms | Within 2 h of ingestion | Generally hours or days postingestion |
| Resolution of symptoms | Usually resolve within 12 h | May continue for many days |
| Symptoms | Gastrointestinal such as vomiting, pain and diarrhoea | Often non-specific symptoms. These can include diarrhoea, vomiting, colic/pain, blood in the stool, gastroesophageal reflux and food refusal or aversion |
| Cutaneous such as urticaria, angioedema, pruritus | ||
| Respiratory such as acute rhinoconjunctivitis, wheezing, coughing, stridor | ||
| Cardiovascular such as collapse as a result of hypotension | ||
| Diagnostic tests | Serum-specific IgE (‘RAST’), skin prick test, open food challenge | Elimination diet (2–6 weeks) followed by reintroduction |
| Examples of clinical phenotypes | Acute urticaria and angioedema, anaphylaxis, oral allergy syndrome | Food protein–induced proctocolitis, food protein–induced enterocolitis syndrome, food protein–induced enteropathy, allergic dysmotility |