Table 1

Differences between IgE- and non–IgE-mediated food allery7 13

IgE mediatedNon–IgE mediated
 Onset of symptomsWithin 2 h of ingestionGenerally hours or days postingestion
 Resolution of symptomsUsually resolve within 12 hMay continue for many days
 SymptomsGastrointestinal such as vomiting, pain and diarrhoeaOften non-specific symptoms. These can include diarrhoea, vomiting, colic/pain, blood in the stool, gastroesophageal reflux and food refusal or aversion
Cutaneous such as urticaria, angioedema, pruritus
Respiratory such as acute rhinoconjunctivitis, wheezing, coughing, stridor
Cardiovascular such as collapse as a result of hypotension
Diagnostic testsSerum-specific IgE (‘RAST’), skin prick test, open food challengeElimination diet (2–6 weeks) followed by reintroduction
Examples of clinical phenotypesAcute urticaria and angioedema, anaphylaxis, oral allergy syndromeFood protein–induced proctocolitis, food protein–induced enterocolitis syndrome, food protein–induced enteropathy, allergic dysmotility