Inherited bleeding disorders which may present with bruising
| Bleeding disorder | Incidence |
|---|---|
| von Willebrand disease | 1 in 100 |
| Factor VIII deficiency | 1 in 10 000 |
| Factor IX deficiency | 1 in 50 000 |
| Afibrinogenaemia | 1 in 1 000 000 (homozygous state) |
| Prothrombin deficiency | 1 in 2 000 000 (homozygous state) |
| Factor V deficiency | 1 in 1 000 000 (homozygous state) |
| Factor VII deficiency | 1 in 300 000 to 1 in 500 000 (homozygous state) |
| Factor X deficiency | 1 in 1 000 000 (homozygous state) |
| Factor XI deficiency | 1 in 1 000 000 (homozygous state) |
| Deficiency of factors II, VII, IX, X | <20 kindreds worldwide (homozygous state) |
| Factor XIII deficiency | 1 in 1 000 000 (homozygous state) |
| Alpha-2-antiplasmin deficiency | Extremely rare |
| Plasminogen activator inhibitor-1 deficiency | Extremely rare |
| Disorders of platelet function and inherited thrombocytopenias | For details see Bolton-Maggs et al6 |
| Bernard–Soulier syndrome | <1000 cases worldwide |
| Glanzmann thrombasthenia | <1000 cases worldwide |