Quinine | IV: loading dose of 20 mg/kg (maximum 1.4 g) quinine dihydrochloride in 5% dextrose or dextrose saline infused over 4h, followed by 10 mg/kg every 8h until child can swallow oral quinine |
| Oral: 10 mg/kg of quinine salt (maximum 600 mg) every 8h for 7 days |
And | |
Clindamycin | 7–13 mg/kg/dose (maximum 450 mg) every 8h for 7 days |
Or | |
Doxcycline (if >12 years old) | 200 mg once daily for 7 days |
Or | |
Pyrimethamine-Sulphadoxine (Fansidar®) | up to 4 years and >5 kg ½ tablet as single dose |
5–6 years 1 tablet as single dose |
7–9 years 1½ tablets as single dose |
10–14 years 2 tablets as single dose |
14–18 years 3 tablets as single dose |
Atovaquone-proguanil (Malarone®) | Body weight |
5–8 kg: 2 ‘paediatric’ tablets once daily for 3 days |
9–10 kg: 3 ‘paediatric’ tablets once daily for 3 days |
11–20 kg: 1 ‘standard’ tablet once daily for 3 days |
21–30 kg: 2 ‘standard’ tablets once daily for 3 days |
31–40 kg: 3 ‘standard’ tablets once daily for 3 days |
>40 kg: 4 ‘standard’ tablets once daily for 3 days |
Co-artem (Riamet®) | Body weight |
5–15 kg: 1 tablet initially then 1 tablet at 8, 24, 36, 48 and 60h (total 6 tablets) |
15–25 kg: 2 tablets initially then 2 tablets at 8, 24, 36, 48 and 60h (total 12 tablets) |
25–35 kg: 3 tablets initially then 3 tablets at 8, 24, 36, 48 and 60h (total 18 tablets) |
>35 kg: 4 tablets initially then 4 tablets at 8, 24, 36, 48 and 60h (total 24 tablets) |