Classification of food hypersensitivity reactions
| IgE-mediated, immediate onset, reactions | |
| Gastrointestinal | Gastrointestinal anaphylaxis: symptoms include, vomiting, pain and/or diarrhoea |
| Cutaneous | Urticaria, angioedema, pruritus, morbilliform rashes and flushing |
| Respiratory | Acute rhinoconjunctivitis, wheezing, coughing and stridor |
| Generalised | Anaphylaxis |
| Mixed IgE and cell-mediated, immediate to delayed onset, reactions | |
| Gastrointestinal (GI) | Eosinophilic oesophagitis |
| Cutaneous | Atopic eczema |
| Cell mediated | |
| Gastrointestinal | Food protein-induced enterocolitis, food protein-induced proctocolitis and food protein-induced enteropathy syndrome—which may present with a clinical picture of “sepsis” |
| Respiratory | Food-induced pulmonary haemosiderosis (Heiner syndrome) (rare) —pulmonary haemosiderosis or bleeding in the lower respiratory tract |
| Mechanism uncertain | |
| GI dysmotility | Gastro-oesophageal reflux* |
| Constipation* | |
| Infantile colic* | |
↵* These associations remain controversial.