Table 1

Risk of NEC, death or either with increasing duration of postnatal antibiotics

OutcomesOR per day of antibiotic use (95% CI), all babies*OR per day of antibiotic use (95% CI), intubated >7 days*
NEC1.07 (1.04 to 1.10)1.09 (1.05 to 1.13)
Death1.16 (1.08 to 1.24)1.13 (1.05 to 1.23)
NEC or death1.04 (1.02 to 1.06)1.04 (1.01 to 1.07)
  • * Adjusted for study centre, gestational age, small-for-gestational age status, sex, black race, 5-min Apgar score of >5, rupture of membranes for >24 h, outborn, prenatal steroid treatment, intrapartum antibiotic treatment, maternal hypertension, maternal haemorrhage and multiple birth.