TY - JOUR T1 - Liraglutide does not provide sustainable results for weight improvement in adolescents with obesity JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 232 LP - 232 DO - 10.1136/archdischild-2020-319807 VL - 107 IS - 3 AU - Clare Brady AU - M Guftar Shaikh Y1 - 2022/06/01 UR - http://ep.bmj.com/content/107/3/232.abstract N2 - Review of: Kelly AS, Auerbach P, Barrientos-Perez M, et al. A randomised, controlled trial of liraglutide for adolescents with obesity. N Engl J Med 2020 May;382:2117–2128. DOI: 10.1056/nejmoa1916038. Allocation: Central randomisation using a web-based response system. Randomisation was stratified according to pubertal status and glycaemic status. Setting: 32 sites over five countries (Belgium, Mexico, Russia, Sweden and the USA). Intervention: All participants received lifestyle therapy. 125 were assigned to liraglutide and 126 assigned to the placebo group, receiving a volume matched equivalent. Patients: 251 participants, aged 12 to <18 years. All participants were obese (defined as body mass index (BMI) of 30 or more), stable body weight (self-reported change of less than 5 kg during the 90 days before screening) and poor response … ER -