PT  - JOURNAL ARTICLE
AU  - Andrew James McArdle
AU  - Stephanie Menikou
TI  - What is proteomics?
AID  - 10.1136/archdischild-2019-317434
DP  - 2021 Jun 01
TA  - Archives of disease in childhood - Education & practice edition
PG  - 178--181
VI  - 106
IP  - 3
4099  - http://ep.bmj.com/content/106/3/178.short
4100  - http://ep.bmj.com/content/106/3/178.full
SO  - Arch Dis Child Educ Pract Ed2021 Jun 01; 106
AB  - Proteomics is the study of a large number of proteins in biological systems. We aim to introduce the complex field to paediatricians and present some recent examples of applications to paediatric problems. Various approaches have been used to study proteomes. The current mainstay is tandem mass spectrometry of enzymatically digested proteins (‘bottom-up proteomics’), and we describe the experimental and computational approach further. Proteomics can offer advantages over transcriptomics by giving direct information about proteins rather than RNA; however, typically data are obtained at lower depth and the confident identification of mass spectra can be challenging. Proteomics frequently complements transcriptomics and other -omics. Used effectively, proteomics offers promise to help answer important clinical and biological questions.There are no data in this work