TY - JOUR T1 - Abnormal thyroid function in paediatric practice JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 361 LP - 363 DO - 10.1136/archdischild-2018-316426 VL - 105 IS - 6 AU - Yee Lin Lee AU - Fabian Yap AU - Rashida Farhad Vasanwala Y1 - 2020/12/01 UR - http://ep.bmj.com/content/105/6/361.abstract N2 - Four patients of term gestation were under review following the identification of abnormal thyroid function test (TFT). Patient 1 presented at 2 months of age with prolonged jaundice and cholestatic liver disease. Patient 2 presented at 1 month of age with prolonged jaundice and transaminitis. Both babies were active, thriving and did not have any feeding problems. Patient 3 had respiratory distress with hypotonia at birth and was treated for presumed Group B Streptococcus sepsis during the first week of life. He had soft dysmorphic features of hypertelorism, low set ears and retrognathia, poor suck and oropharyngeal dysphagia. He developed prolonged jaundice with transaminitis at 1 month of age and was developmentally delayed. Patient 4 presented at 19 months of age with faltering growth. Table 1 shows their cord blood thyroid stimulating hormone (TSH) screening and thyroid function trends following their presentation.View this table:In this windowIn a new windowTable 1 Thyroid function trends in these patientsWhat is the most likely diagnosis in these patients?Primary hypothyroidism with delayed TSH rise.Central hypothyroidism.Euthyroid sick syndrome.Thyroid binding globulin deficiency.Transient hypothyroxinaemia.How would you manage them during follow-up? (choosing more than one option is … ER -