TY - JOUR T1 - Salbutamol administered preoperatively to children undergoing tonsillectomy resulted in a significant reduction in rates of respiratory adverse events JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 383 LP - 384 DO - 10.1136/archdischild-2019-318590 VL - 105 IS - 6 AU - Andrew A Tester AU - Anne Devenny AU - Rebecca Dalrymple Y1 - 2020/12/01 UR - http://ep.bmj.com/content/105/6/383.abstract N2 - Review ofVon Ungern-Sternberg BS, Sommerfield D, Slevin L, Drake-Brockman TFE, Zhang G, Hall GL. Effect of albuterol premedication vs placebo on the occurrence of respiratory adverse events in children undergoing tonsillectomies: the REACT randomized clinical trial. JAMA Pediatr 2019 Study design: Randomised, placebo-controlled trial. Participants were randomly allocated to an intervention using computer-generated block randomisation. Initially stratified based on administration method, but due to a change in practice favouring laryngeal mask airways over endotracheal tubes, in all ages, this was ceased. Study question: To ascertain whether preoperative inhaled salbutamol reduces the rates of perioperative respiratory events in children undergoing tonsillectomies under general anaesthesia. Setting: Perth Children’s Hospital, Western Australia. Participants: 484 children, aged 0–8 years, undergoing general anaesthesia for tonsillectomy (+/− other ENT procedures including adenoidectomy). Intervention: Preoperative administration of salbutamol (200 µg), administered via a metered … ER -