RT Journal Article SR Electronic T1 Fifteen-minute consultation: Management of the infant born to a mother with toxoplasmosis in pregnancy JF Archives of disease in childhood - Education & practice edition JO Arch Dis Child Educ Pract Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 262 OP 269 DO 10.1136/archdischild-2018-316603 VO 105 IS 5 A1 Anja Saso A1 Alasdair Bamford A1 Karen Grewal A1 Muna Noori A1 James Hatcher A1 Felice D'Arco A1 Edward Guy A1 Hermione Lyall YR 2020 UL http://ep.bmj.com/content/105/5/262.abstract AB Congenital toxoplasmosis occurs following transplacental transfer of Toxoplasma gondii. Irrespective of symptom status at birth, infants with congenital infection may develop serious long-term sequelae, including learning disability, seizures, hydrocephalus, motor and hearing deficits, chorioretinitis and retinal scarring with impaired vision. Timely diagnosis facilitates early initiation of therapy, aimed at prevention or amelioration of adverse clinical consequences. Diagnosis can be difficult, however, since acutely infected mothers are often asymptomatic and laboratory testing can be complex. Moreover, any decision to start treatment in the newborn must include careful consideration of the benefits and risks. This paper outlines a structured approach for managing an infant born to a woman with possible or confirmed T. gondii infection during pregnancy, including key aspects of the antenatal history, interpretation and timing of investigations, treatment and appropriate follow-up. Our recommendations are based on current evidence in the literature, consensus from two UK paediatric infectious disease centres and the UK specialist Toxoplasma Reference Unit.