@article {Saso262, author = {Anja Saso and Alasdair Bamford and Karen Grewal and Muna Noori and James Hatcher and Felice D{\textquoteright}Arco and Edward Guy and Hermione Lyall}, title = {Fifteen-minute consultation: Management of the infant born to a mother with toxoplasmosis in pregnancy}, volume = {105}, number = {5}, pages = {262--269}, year = {2020}, doi = {10.1136/archdischild-2018-316603}, publisher = {Royal College of Paediatrics and Child Health}, abstract = {Congenital toxoplasmosis occurs following transplacental transfer of Toxoplasma gondii. Irrespective of symptom status at birth, infants with congenital infection may develop serious long-term sequelae, including learning disability, seizures, hydrocephalus, motor and hearing deficits, chorioretinitis and retinal scarring with impaired vision. Timely diagnosis facilitates early initiation of therapy, aimed at prevention or amelioration of adverse clinical consequences. Diagnosis can be difficult, however, since acutely infected mothers are often asymptomatic and laboratory testing can be complex. Moreover, any decision to start treatment in the newborn must include careful consideration of the benefits and risks. This paper outlines a structured approach for managing an infant born to a woman with possible or confirmed T. gondii infection during pregnancy, including key aspects of the antenatal history, interpretation and timing of investigations, treatment and appropriate follow-up. Our recommendations are based on current evidence in the literature, consensus from two UK paediatric infectious disease centres and the UK specialist Toxoplasma Reference Unit.}, issn = {1743-0585}, URL = {https://ep.bmj.com/content/105/5/262}, eprint = {https://ep.bmj.com/content/105/5/262.full.pdf}, journal = {Archives of Disease in Childhood - Education and Practice} }