TY - JOUR T1 - Prophylactic platelet transfusion at higher thresholds was associated with increased risk of death or major bleeding in neonates JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 127 LP - 128 DO - 10.1136/archdischild-2019-316838 VL - 105 IS - 2 AU - Abdul Razak AU - Ishrat Rahman Y1 - 2020/04/01 UR - http://ep.bmj.com/content/105/2/127.abstract N2 - Should preterm infants (less than 34 weeks gestational age) with significant thrombocytopenia but no major bleeding receive prophylactic platelet transfusion at a threshold below 25 x109/L  or below 50 x109/L ?1 Design: Randomised clinical trial.Patients Inclusion criteria: Preterm infants less than 34 weeks’ gestational age admitted in neonatal intensive care unit with a platelet count of less than 50 000 per mm3 but no major intraventricular haemorrhage within 6 hours of randomisation. Exclusion criteria: Major life-threatening congenital malformation, major bleeding within previous 72 hours, fetal intracranial haemorrhage, immune thrombocytopenia, infants who did not receive parenteral vitamin K or a low probability of survival beyond several hours. Infants with major bleeding included 72 hours later provided there was no further major bleeding. Interventions: Infants received 15 mL/kg of body weight of platelet transfusion if the platelet counts were less than 25 x109/L (the low-threshold group) or less than 50 x109/L (the high-threshold group). Outcomes: The primary outcome was death … ER -