TY - JOUR T1 - Critically ill children did not benefit from tight glycaemic control JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 336 LP - 336 DO - 10.1136/archdischild-2017-313012 VL - 102 IS - 6 AU - Angela Katrina Lucas-Herald AU - Kenneth J Robertson AU - Angela Katrina Lucas-Herald Y1 - 2017/12/01 UR - http://ep.bmj.com/content/102/6/336.2.abstract N2 - Design: Randomised controlled trial. Allocation: Computer generated block design. Setting: Thirty-five paediatric intensive care unit (ICU) centres. Patients: Three hundred and sixty patients (median age 5.5 years, IQR 1.4–12.5 years) in the lower target group; 353 patients (median age 6.7 years, IQR 1.7–12.8 years) in the higher target group. Intervention: Randomisation to low target glycaemic control group (80–110 mg/dL (4.4–6.1 mmol/L)) or higher target glycaemic control group (150–180 mg/dL (8.3–10 mmol/L). Outcomes: Primary outcome: number of ICU-free days to day 28. Prespecified secondary outcomes: 90-day mortality, severity of organ dysfunction, the number of ventilator-free days to day 28, incidence of healthcare-associated infection and incidence of hypoglycaemia. Patient follow-up: Patients were followed up for 90 days. Recruitment stopped at … ER -