RT Journal Article
SR Electronic
T1 Fifteen-minute consultation: diagnosis and management of congenital CMV
JF Archives of disease in childhood - Education & practice edition
JO Arch Dis Child Educ Pract Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 232
OP 235
DO 10.1136/archdischild-2015-309656
VO 101
IS 5
A1 Tejshri Shah
A1 Suzanne Luck
A1 Mike Sharland
A1 Seilesh Kadambari
A1 Paul Heath
A1 Hermione Lyall
YR 2016
UL http://ep.bmj.com/content/101/5/232.abstract
AB Congenital cytomegalovirus (cCMV) infection can result in permanent neurological problems and is a potentially preventable cause of sensorineural hearing loss in the UK. There is an urgency to diagnose and assess cCMV as antiviral treatment and has only been shown to be effective if started in the first 4 weeks of life. A recent randomised controlled trial of 6 months of treatment using oral valganciclovir has shown modest benefit in preventing hearing deterioration and in improving some neurodevelopmental outcomes. Parents and clinicians need to make a timely and informed choice regarding antiviral treatment and ensure that relevant non-pharmaceutical interventions are considered. This paper brings together the current evidence regarding the diagnosis and treatment of cCMV, consensus from two paediatric infectious diseases centres and outlines research priorities.