RT Journal Article
SR Electronic
T1 Fitting and flailing: recognition of paediatric antiphospholipid syndrome
JF Archives of disease in childhood - Education & practice edition
JO Arch Dis Child Educ Pract Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 28
OP 36
DO 10.1136/archdischild-2012-302404
VO 99
IS 1
A1 H Freeman
A1 J Patel
A1 D Fernandez
A1 P Sharples
A1 A V Ramanan
YR 2014
UL http://ep.bmj.com/content/99/1/28.abstract
AB Antiphospholipid syndrome (APS) is a systemic autoimmune condition where the presence of antiphospholipid antibodies is thought to predispose to thrombotic events. It is uncommon in the paediatric population, but current diagnostic criteria are based on adult population studies, making assessment of its true paediatric prevalence difficult. We present two cases of paediatric APS, who presented with primary neurological events, and discuss approaches to diagnosis, interpretation of screening investigations, including antinuclear antibodies (ANA), anti-extractable nuclear antigen (ENA) antibodies and lupus anticoagulant. Possible approaches to the management of paediatric APS are discussed.