PT  - JOURNAL ARTICLE
AU  - Sam Behjati
AU  - Patrick S Tarpey
TI  - What is next generation sequencing?
AID  - 10.1136/archdischild-2013-304340
DP  - 2013 Dec 01
TA  - Archives of disease in childhood - Education & practice edition
PG  - 236--238
VI  - 98
IP  - 6
4099  - http://ep.bmj.com/content/98/6/236.short
4100  - http://ep.bmj.com/content/98/6/236.full
SO  - Arch Dis Child Educ Pract Ed2013 Dec 01; 98
AB  - Next generation sequencing (NGS), massively parallel or deep sequencing are related terms that describe a DNA sequencing technology which has revolutionised genomic research. Using NGS an entire human genome can be sequenced within a single day. In contrast, the previous Sanger sequencing technology, used to decipher the human genome, required over a decade to deliver the final draft. Although in genome research NGS has mostly superseded conventional Sanger sequencing, it has not yet translated into routine clinical practice. The aim of this article is to review the potential applications of NGS in paediatrics.