TY - JOUR T1 - Intensive insulin therapy-reduced mortality in patients in paediatric intensive care JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 21 LP - 21 DO - 10.1136/adc.2010.189183 VL - 96 IS - 1 A2 - , Y1 - 2011/02/01 UR - http://ep.bmj.com/content/96/1/21.abstract N2 - Design Single centre randomised controlled trial, stratified by diagnostic category and age, comparing conventional or intensive insulin treatment. Allocation Concealed allocation by envelopes. Blinding Blinding not stated. Setting Paediatric intensive care unit (PICU) in a Belgian University hospital. Patients 700 critically ill children, 317 infants <1 year and 383 children >1 year. Intervention (1) Conventional group, insulin infusion commenced for blood glucose concentration >11.9 mmol/l twice and dose adjusted to maintain blood glucose 10.0–11.9 mmol/l. (2) Intensive insulin group, insulin infused at 0.1 U/kg/h to target age-adjusted normoglycaemia: for infants aged 0–1 year 2.8–4.4 mmol/l and for children aged 1–16 years 3.9–5.5 mmol/l. If hypoglycaemic, then infusion stopped and 50% dextrose given. View this table:In this windowIn a new window Outcomes In-hospital morbidity, PICU mortality and length of stay. C-reactive protein, duration of mechanical ventilation and vital organ support and markers of organ dysfunction were also recorded. Adverse events included hypoglycaemic episodes. Follow-up period Until PICU discharge. Insulin therapy was administered in … ER -