TY - JOUR T1 - Genetics of hypertrophic cardiomyopathy of childhood onset JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 128 LP - 128 VL - 93 IS - 4 A2 - , Y1 - 2008/08/01 UR - http://ep.bmj.com/content/93/4/128.abstract N2 - It is unusual for hypertrophic cardiomyopathy to become manifest before the age of 14 years. The adult-onset disease is caused by mutations in any of a number of genes that encode sarcomere proteins. These include the genes for cardiac β-myosin heavy chain (MYH7), cardiac myosin-binding protein C (MYBPC3), cardiac troponin T (TNNT2), cardiac troponin 1 (TNNI3), essential myosin light chain (MYL3), regulatory myosin light chain (MYL2), α tropomyosin (TPM1), cardiac actin (ACTC) and titin (TTN). Gene mutations known … ER -