TY - JOUR T1 - Lansoprazole for children with poorly controlled asthma JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 199 LP - 199 DO - 10.1136/archdischild-2013-304692 VL - 98 IS - 5 A2 - , Y1 - 2013/10/01 UR - http://ep.bmj.com/content/98/5/199.abstract N2 - Design: Randomised placebo-controlled trial (RCT). Allocation: 1:1 ratio of intervention:placebo using permuted-block assignment stratified by clinical centre. Setting: 19 American Lung Association Asthma Clinical Research Center sites from April 2007 to April 2011. Patients: Children aged 6–17 years (mean 11 years) with physician and lung function confirmed poorly controlled asthma, all of whom had been treated with inhaled corticosteroids for at least 8 weeks prior to enrolment. Patients with current or previous gastro-oesophageal reflux disease requiring treatment were excluded. A subgroup of 115 received pH studies. Intervention: 149 children received lansoprazole (15 mg/day <30 kg or 30 mg/day >30 kg) and 157 received placebo. Outcomes: Primary outcome—Change in Asthma Control Questionnaire (ACQ) score. Secondary outcomes—Rate of episodes of acute asthma, asthma symptom utility index, asthma control test for adolescents, asthma-specific quality of life for children score, meaningful clinically important changes in lung function tests, gastrointestinal symptoms or nocturnal awakenings. Follow-up period: … Correspondence to Dr Cara Bossley, Department of Paediatrics, King's College Hospital, London, UK; cara.bossley{at}nhs.net ER -