TY - JOUR T1 - Fifteen-minute consultation on the infant with a large head JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 122 LP - 125 DO - 10.1136/archdischild-2013-303910 VL - 98 IS - 4 AU - Arnab Seal Y1 - 2013/08/01 UR - http://ep.bmj.com/content/98/4/122.abstract N2 - An infant with a large head (2.5 SDs above normal for weight and gender or above 99.6th centile for age) is a common clinical presentation. Usually, it is due to benign isolated macrocephaly or familial macrocephaly (FM) where some close family members are similarly affected1; neither condition requires any further intervention. However, there are a few important underlying causes the clinician needs to actively consider and investigate when indicated before reassuring parents. These considerations include whether there is any associated developmental disorder or suggestion of a syndromic association or evidence of raised intracranial pressure (ICP). In most instances, a careful history and examination either clarifies the diagnosis; for example, an ex-preterm child developing hydrocephalus. In other instances, it provides pointers for further investigation and management, for example, arranging genetic tests in a child presenting with macrocephaly and multiple cafe au lait spots suggesting the possible diagnosis of neurofibromatosis (NF) Type 1. The following considerations are helpful. Is the head … ER -