TY - JOUR T1 - How to use: C-reactive protein JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 55 LP - 58 DO - 10.1136/adc.2009.174367 VL - 95 IS - 2 AU - S McWilliam AU - A Riordan Y1 - 2010/04/01 UR - http://ep.bmj.com/content/95/2/55.abstract N2 - C-reactive protein (CRP) is an acute-phase protein that increases 4–6 h after an inflammatory trigger and peaks at 36–50 h. Levels decrease rapidly with the resolution of inflammation. CRP is generally highly elevated in invasive bacterial infections and is often used as a marker of inflammation. A single CRP level is neither sensitive nor specific enough to identify all children with serious bacterial infection. However, a raised CRP does suggest serious bacterial infection and should suggest further assessment is needed. CRP levels that fail to decrease, or continue to rise, after 48 h of antibiotic therapy suggest treatment failure. In infants with suspected neonatal sepsis, two CRP measurements 24 h apart that are <10 mg/l are useful in excluding sepsis. ER -