TY - JOUR T1 - In infants with ‘colic’/persistent crying, administration of daily <em>Lactobacillus reuteri</em> DSM 17938 was associated with reduced crying time at 1, 2 and 3 weeks JF - Archives of disease in childhood - Education &amp; practice edition JO - Arch Dis Child Educ Pract Ed SP - 239 LP - 239 DO - 10.1136/archdischild-2011-300204 VL - 96 IS - 6 A2 - , Y1 - 2011/12/01 UR - http://ep.bmj.com/content/96/6/239.abstract N2 - Design: Single centre randomised controlled trial.Allocation: Computer generated random-digit randomisation.Blinding: Participants, physicians and statisticians.Setting: Tertiary hospital paediatric outpatient department, Turin, Italy, March 2008 to August 2009.Patients: Breast-fed infants (n=46) aged 2–16 weeks with persistent crying fulfilling Wessel's criteria for colic: crying for more than 3 h/day for more than 3 days/week for more than 3 weeks.Intervention: A 5 ml oil suspension of Lactobacillus reuteri or an identically appearing and tasting placebo oil.Outcomes: Primary: Reduction in mean daily crying time at day 21 of treatment to less than 3 h/day. Secondary: Reduction in daily mean crying time to less than 50% of baseline at 7, 14 and 21 days.Follow-up period: 21 days. By day 21 median crying times were … Correspondence to Dr Nick Brown, Paediatric Department, Salisbury District Hospital, Salisbury SP2 8BJ, UK; n_janbrown{at}yahoo.co.uk ER -