TY - JOUR T1 - Isoniazid prophylaxis started at 3–4 months of life does not prevent tuberculosis disease or infection in both HIV-infected and uninfected children JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 40 LP - 40 DO - 10.1136/archdischild-2012-302876 VL - 98 IS - 1 A2 - , Y1 - 2013/02/01 UR - http://ep.bmj.com/content/98/1/40.abstract N2 - Setting: South Africa and Botswana Patients: The study looked at infants who were born to HIV-infected women. To be included in the study, the infants had to be between 91 and 120 days of life, not infected with or exposed to a case of tuberculosis, without other chronic illness, or immunosuppressed from an infection other than HIV. A total of 1351 children were included in the analysis and were split into two groups based on their HIV status after testing: HIV positive and HIV negative (table 1). Intervention: The infants in both groups were randomly assigned to receive either isoniazid at a daily dose of 10–20 mg/kg or placebo. The study drug was initiated four days into randomisation, and continued for 96 weeks in total. All HIV-infected children continued to have access to … Correspondence to Dr Mildred Adaku Iro, Department of Paediatrics, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK; adakuiroh{at}yahoo.com ER -