TY - JOUR T1 - Hypothermia did not improve mortality or disability in severe traumatic brain injury JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 119 LP - 119 DO - 10.1136/archdischild-2013-305596 VL - 99 IS - 3 A2 - , Y1 - 2014/06/01 UR - http://ep.bmj.com/content/99/3/119.abstract N2 - Design: Randomised controlled trial (RCT). Allocation: Concealed web based algorithm to stratified by study site and age. Blinding: Treating doctors not masked—investigators assessing outcome were masked. Setting: Multinational, multicentre paediatric intensive care unit—75% patients from three paediatric intensive care units (Davis, California; Dallas, Texas; Pittsburgh, Pennsylvania) in USA. Patients: Age 0–17 years non-penetrating brain injury; Glasgow coma scale (GCS) score 3–8 (motor score <6), available for randomisation within 6 h of injury. Excluded if any of: normal CT head, Glasgow coma scale score 3, unreactive pupils, hypotension, uncorrectable coagulopathy, hypoxia, multiple trauma, suspected pregnancy. Intervention: Thirty-nine patients were randomised to hypothermia (T32–33°C) for 48 h followed by slow rewarming and 38 patients were randomised to … ER -