TY - JOUR T1 - Answers to Dermatophile JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed SP - 224 LP - 225 DO - 10.1136/archdischild-2014-307368a VL - 100 IS - 4 AU - Vânia Oliveira Carvalho AU - Renata Robl AU - Marjorie Uber AU - Kerstin Taniguchi Abagge AU - Leide Parolin Marinoni AU - Juliana Gomes Loyola Presa Y1 - 2015/08/01 UR - http://ep.bmj.com/content/100/4/224.abstract N2 - From the questions on page 185.B—Langerhans cell histiocytosis (LCH): Abnormal clonal proliferation of histiocytes, resembling Langerhans cells, and its accumulation in different tissues and organs. LCH exhibits heterogeneous clinical pictures and evolution—it varies from the isolated cutaneous lesion with spontaneous resolution to severe cases involving the liver, spleen, lung and haematopoietic system.1 The most common skin lesion is similar to seborrhoeic dermatitis, but exhibits petechiae and purpura, and affects the scalp, eyebrows, ears and intertriginous areas.2 Seborrhoeic-like plaques resistant to conventional therapy, no improvement until 8 months of age (both facts described in case number 1), as well as the presence of hepatosplenomegaly should indicate the hypothesis of LCH and, therefore, skin biopsy … ER -