37 e-Letters

published between 2010 and 2013

  • How to use CRP - authors reply
    Andrew Riordan

    We were grateful to a number of people who contacted us about our article on How to use C - reactive protein [1].

    Dr Abelian of Wrexham Maelor Hospital drew out attention to data on plasma half-life suggesting this was 19 hours in an adult [2] rather than the previously quoted 4-7 hours [3,4].

    Dr Emmerson asked if there was robust data in support of the range of non infectious conditions quoted to cause...

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  • CRP is a useful marker in preterm infants
    David Burgner

    Dear Editors

    Re: How to use: C-reactive protein. McWilliam, et al. 95:55-58

    McWilliam and Riordan recently reviewed the use and limitations of C- reactive protein (CRP) in clinical practice, particularly in the diagnosis of infection.(1) The authors imply the authors suggest preterm infants cannot mount a CRP response (CRP levels remain low) when compared to term infants and older children. In the cont...

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  • automated reporting of QT interval and other issues in the channelopathies
    oscar,m jolobe

    The recommendation that a 12-lead electrocardiogram(ECG) should be performed on every patient presenting with transient loss of consciousness(TLOC)(1)) is a sound one, regardless of whether the provisional diagnosis is syncope or epilepsy, given the fact that convulsive syncope can simulate epilepsy(1). An important caveat regarding investigation of underlying causes of TLOC using the 12 lead ECG in settings such as the...

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  • Erratum: Commentator Omitted
    Bob Phillips
    Please note the commentary on this article was written by:

    Prof. Bill McGuire
    Professor of Paediatrics and Child Health Hull York Medical School / Centre for Reviews and Dissemination
    University of York
    YO10 5DD

    We unreservedly apologise for the omission of his name and designation on this Picket.

    Conflict of Interest:

    None declared

  • CRP - a marker of systemic inflammation
    Jonathan L Marks

    Dear Editor we read with interest the recent article regarding how to use C- reactive protein (CRP). While the authors discuss the role of CRP as a non-specific indicator of serious bacterial infection (SBI) they do not acknowledge that CRP is a non-specific indicator of systemic inflammation, the causes of which are many and varied with acute infective processes being only one.

    It is important to consider alter...

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  • CRP and the Newborn Infant
    Anthony J Emmerson

    I was interested in the excellent article on How to use C-Reactive Protein in Education and Practice by McWilliam and Riordan. I was particularly interested in your comments in the article on Ruling in Sepsis and the comment that CRP is not diagnostic for sepsis in the neonate because it may be raised for other reasons. The article quotes - prolonged rupture of membranes - (most frequently caused by local sepsis and is...

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  • bottom line: Not practical
    Ganesh Sambandamoorthy

    Dear Dr. Acheson

    Many thanks for an excellent update on Appendicitis. Only comment I would like to make is about the bottom line.

    A review by a paediatric surgeon for all suspected Appendicitis to decide on further management is almost impossible in the existing NHS. I have worked in 5 different DGH's and one Children's hospital A&E. In DGH, its hard to get a paediatric surgeons review even for pro...

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