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Study design: Twin-centre retrospective analysis.
Setting: Two urban academic children’s hospitals in the USA.
Patients: 2345 children diagnosed with type 1 diabetes mellitus (T1DM) <18 years old and at least 1-year duration of diabetes between 2006 and 2019.
Outcomes: The primary outcomes were incidence of acute kidney injury (AKI) and presence of microalbuminuria. AKI diagnosis was based on Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria. Microalbuminuria was defined as urine albumin to creatinine ratio of ≥30 mg/g or excretion of ≥30 mg of albumin in 24 hours.
Follow-up: The mean (SD) duration of follow-up was 6.5 (3.5) years.
Main results: AKI occurred in 560 (47%) episodes of …
Review of article Huang JX, Casper TC, Pitts C, et al. Association of acute kidney injury during diabetic ketoacidosis with risk of microalbuminuria in children with type 1 diabetes. JAMA Pediatr 2022;176:169–175
Contributors ALH wrote the first draft and JM edited.
Provenance and peer review Commissioned; internally peer reviewed.