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Acute kidney injury during diabetic ketoacidosis increased the risk of microalbuminuria in children with type 1 diabetes mellitus
  1. Alyce Louise Hayes,
  2. Joseph McAllister
  1. Paediatrics, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Dr Alyce Louise Hayes, Paediatrics, Leeds Teaching Hospitals NHS Trust, Leeds, UK; alyce.hayes{at}nhs.net

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Study design: Twin-centre retrospective analysis.

Setting: Two urban academic children’s hospitals in the USA.

Patients: 2345 children diagnosed with type 1 diabetes mellitus (T1DM) <18 years old and at least 1-year duration of diabetes between 2006 and 2019.

Outcomes: The primary outcomes were incidence of acute kidney injury (AKI) and presence of microalbuminuria. AKI diagnosis was based on Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria. Microalbuminuria was defined as urine albumin to creatinine ratio of ≥30 mg/g or excretion of ≥30 mg of albumin in 24 hours.

Follow-up: The mean (SD) duration of follow-up was 6.5 (3.5) years.

Main results: AKI occurred in 560 (47%) episodes of …

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Footnotes

  • Review of article Huang JX, Casper TC, Pitts C, et al. Association of acute kidney injury during diabetic ketoacidosis with risk of microalbuminuria in children with type 1 diabetes. JAMA Pediatr 2022;176:169–175

  • Contributors ALH wrote the first draft and JM edited.

  • Provenance and peer review Commissioned; internally peer reviewed.