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Review of: Kirpalani H, Bell EF, Hintz SR, et al. Higher or lower hemoglobin transfusion thresholds for preterm infants. N Engl J Med 2020;383:2639–51. doi:10.1056/nejmoa2020248
Design: Open multicentre randomised clinical trial.
Allocation: Central telephone randomisation, stratified according to trial centre and birth weight (<750 g or 750–1000 g). Infants were assigned in a 1:1 ratio.
Blinding: Follow-up assessments were masked to the intervention.
Study question: Does a higher haemoglobin threshold for red-cell transfusions reduce the risk of cognitive delay among extremely low-birth-weight infants with anaemia?
Setting: 41 NICUs (19 centres) in a Neonatal Research Network in the USA.
Patients: 1824 infants aged under 48 hours with a birth weight less than 1001 g and gestational age 22+0 to 28+6 weeks. Infants with cardiac conditions, family history of haemoglobinopathy, prior transfusions or significant …
Contributors Both authors contributed equally to the manuscript.
Provenance and peer review Not commissioned; internally peer reviewed.