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Macrolides in children: judicious use, avoiding resistance and reducing adverse effects
  1. Anisha Patel1,
  2. Kevin Meesters2
  1. 1 Pharmacy, Evelina London Children's Hospital, London, UK
  2. 2 Paediatric Infectious Diseases and Immunology, Evelina London Children's Hospital, London, UK
  1. Correspondence to Dr Kevin Meesters, Paediatric Infectious Diseases and Immunology, Evelina London Children's Hospital, London SE1 7EH, UK; Kevin.Meesters{at}nhs.net

Abstract

Macrolides, a group of antibiotics molecularly characterised by a macrocyclic ring, are among the most frequently prescribed antibiotics for children. Beyond their antibacterial action, macrolides exert immunomodulatory effects. Prophylactic use is increasing. Macrolides are usually well tolerated in children, and dosing schedules are convenient. Furthermore, increasing data suggests that their prophylactic usage reduces the exacerbation frequency in children with bronchiectasis. Yet, to preserve their antibacterial action, each macrolide prescription should be judiciously considered. For prophylactic use, the indication should be regularly reviewed, and usage longer than 6 months should be avoided to reduce antimicrobial resistance.

  • pharmacology
  • microbiology

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Footnotes

  • Contributors Both authors contributed equally.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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